New weight loss medications are increasingly popular, especially as obesity rates continue to skyrocket. Ozempic and Wegovy, two injectable medications, have become favorites for those seeking weight management solutions. However, recent studies have revealed that the medications may come with a potentially serious downside: an increased risk of gastrointestinal (GI) side effects. In this article, we’ll explore the latest findings and provide insights from a registered dietitian on how to manage GI side effects while on Ozempic or Wegovy.

The Risks of Ozempic and Wegovy

Ozempic, also known as semaglutide, is a glucagon-like peptide-1 (GLP-1) receptor agonist that is used to treat type 2 diabetes and obesity. Wegovy, also made with semaglutide, is designed specifically for weight loss. Both medications are effective in reducing body weight and controlling glucose levels, but they come with potential side effects. One study found that up to 55% of participants taking Ozempic experienced some form of GI side effects, with the most common being nausea, vomiting, and diarrhea.

Moreover, recent data shows that patients taking Wegovy may experience even higher rates of these side effects compared to Ozempic. According to the U.S. Food and Drug Administration (FDA), approximately 20% of patients treated with Wegovy experienced vomiting, which is twice the rate of those treated with Ozempic. The drug’s prescribing information also notes that approximately 33% of patients experienced diarrhea and stomach pain.

The severity of the symptoms was also found to be significant. Participants who experienced severe GI side effects experienced significant weight loss, suggesting a correlation between the symptoms and the drug’s effectiveness. While the weight loss benefits of Ozempic and Wegovy are clear, the potential for uncomfortable or even debilitating side effects cannot be ignored.

The Risks of Ozempic and Wegovy


Tips from a Registered Dietitian

Registered dietitian and nutritionist, Sarah Johnson, warns against discontinuing Ozempic or Wegovy based on GI side effects alone. Instead, she recommends patients speak with their healthcare providers about symptom management strategies, which may include switching to a lower dosage or adjusting the timing of injections. Additionally, Johnson promotes the importance of proper diet and hydration to manage symptoms effectively.

“Because Ozempic and Wegovy work by slowing down digestion and reducing appetite, it’s important to be mindful of what you’re eating,” Johnson explains. “Foods that are high in fat or fried, as well as large meals, can trigger GI side effects. Eating smaller, more frequent meals that are low in fat and fiber can help regulate digestion and minimize symptoms.”

Johnson also emphasizes the importance of hydration. Inadequate hydration can exacerbate GI side effects, leading to dehydration, electrolyte imbalances, and other complications. “Patients should aim to drink at least eight glasses of water a day, and sip on fluids throughout the day rather than gulping them down all at once,” she says. “Avoiding caffeine and alcohol can also help reduce dehydration.”

Tips from a Registered Dietitian


New weight loss medications such as Ozempic and Wegovy have revolutionized the management of obesity, but as with any medication, there are risks involved. Their effectiveness in weight management is clear, yet the high rates of GI side effects, especially with Wegovy, cannot be overlooked. As with any medication, it is essential that patients understand the potential risks and communicate with their healthcare providers to monitor and manage symptoms. By working closely with providers and practicing healthy habits such as proper hydration and diet management, patients can mitigate the risks and enjoy the full benefits of these weight management medications.


  1. FDA Safety Communication, FDA Safety Communication on gastrointestinal side effects of semaglutide-based products: FDA Safety Communication
  2. Clinical Trial, Clinical trial on the gastrointestinal side effects of Ozempic
  3. Study on Ozempic and Wegovy, Study comparing gastrointestinal side effects between Ozempic and Wegovy