Cases of the Pirola variant, a sub-lineage of the BA.2.86 variant, have tripled in recent weeks, leading to concerns among global health authorities. When it comes to COVID-19, “variants” are strains of the virus that have mutated from the original virus. As such, they can show differences in how they spread and how effective vaccines and treatments are against them.

In this article, we will explore what the Pirola variant is, how it differs from other COVID-19 variants, and what we know about its potential dangers. We will also look at the recent upsurge in cases of the variant, what efforts public health officials are taking to track, contain, and prevent its spread.

What is the Pirola variant?

The Pirola variant is a sub-lineage of the BA.2.86 variant, which itself is a descendant of the Alpha variant (first detected in the United Kingdom late last year). According to the World Health Organization (WHO), it has the following mutations: T19R, Q613H, and S982A.

One of the key differences between the Pirola variant and other variants of COVID-19 is that it appears to have a mutation in the spike protein that makes it harder for antibodies to attach to the virus and neutralize it. This means that it could potentially be more resistant to antibodies produced by the current vaccines or natural immunity obtained from previous infection.

What are the potential dangers of the Pirola variant?

As of right now, we don’t know for sure what dangers the Pirola variant poses that other variants do not. However, one reason for the concern surrounding the variant is that mutations in the spike protein could potentially lead to reduced vaccine effectiveness.

Recently, the European Union warned that the Pirola variant may be “highly transmissible” and “may affect the diagnosis, treatment, and efficacy of vaccines.” In Italy, where the Pirola variant was first identified, researchers are investigating whether the virus is more likely to cause severe disease or death than other strains.

The potential dangers of the variant are still being studied, and more research is needed to understand its true impact. However, it is clear that this variant is an emerging threat and requires vigilant monitoring by health officials.

What are the potential dangers of the Pirola variant?

Recent Surge in Cases:

In recent weeks, cases of the Pirola variant have tripled in Italy, where it was first identified. According to data released by the Italian Health Ministry, the variant now makes up around 20% of all COVID-19 cases in the country. Experts warn that if the current trend continues, the Pirola variant could become the dominant strain in Italy and possibly other parts of Europe.

Health officials believe that the recent surge in cases of the Pirola variant is due to it being highly transmissible, and they have urged people to continue following public health guidelines, such as wearing masks, social distancing, and washing hands. Italy has also implemented quarantine measures for travelers arriving from countries where the variant is prevalent in an effort to curb its spread.

Efforts to Contain and Prevent Spread:

While the Pirola variant has raised concerns, efforts are being made to contain and prevent its spread. Public health officials in Italy and other countries are working to identify cases, investigate possible transmission chains, and increase testing and contact tracing efforts.

The European Union has also issued new recommendations for member states to quickly identify and sequence COVID-19 variants, including the Pirola variant. These efforts are crucial to tracking the spread of the virus and identifying potential outbreaks.

In addition, scientists are currently studying the potential effectiveness of vaccines against the Pirola variant. Studies have shown that the Pfizer-BioNTech COVID-19 vaccine, one of the most widely used vaccines globally, is effective against the BA.2.86 variant, of which the Pirola variant is a sub-lineage. However, more research is needed to determine the vaccine’s efficacy against the Pirola variant specifically.

Efforts to Contain and Prevent Spread


The Pirola variant is a sub-lineage of the BA.2.86 variant that has recently seen a surge in cases in Italy and raises concerns for potential danger and resistance to vaccines. While it is still too early to know the full impact of the Pirola variant, public health officials and scientists are working diligently to contain its spread and determine its true impact on vaccine effectiveness. Vigilant monitoring of emerging variants and continued efforts to follow public health guidelines are necessary to reduce transmission and prevent the development of more dangerous strains.


  1. World Health Organization, Tracking SARS-CoV-2 variants
  2. Centers for Disease Control and Prevention (CDC), COVID-19